The Ferruginous Hawk (Buteo regalis) may be particularly sensitive to human disturbance, but is also a highly versatile nester. South-central Wyoming supports one of the largest breeding populations of Ferruginous Hawks, as well as significant natural-gas development. Ferruginous Hawks were first documented nesting on natural-gas structures in the area during the 1980’s. Because nests on natural-gas structures commonly failed due to human activities, the Rawlins Field Office of the Bureau of Land Management installed 105 artificial nest structures (ANSs) between 1987 and 2004 to provide area birds with viable nesting alternatives. Herein we draw on previous research to assess the efficacy of ANSs as a mitigation tool. Overall, Ferruginous Hawks used 85% of all available ANSs for nesting at some point. Nesting activity appeared to be positively associated with areas of natural-gas development and subsequent ANS installation. However, activity patterns at nest clusters (see definitions) with and without ANSs exhibited opposite relationships with development and drought. Productivity was significantly greater at ANSs relative to ground or rock-feature nests, and both nest success and productivity were greater at inaccessible (to mammalian predators) nests compared to accessible nests. Ferruginous Hawks utilizing ANSs maintained fewer alternate nests. Nest attendance and prey delivery were greater at ANSs and other inaccessible nests, likely contributing to their greater success and productivity. Our research suggests that birds in the study area responded rapidly to newly available man made structures and fared well on ANSs. We suggest that the rapid shift to natural gas structures and ANSs was likely due to their location within attractive foraging habitat lacking natural nest sites. Despite the apparent success of this ANS program, we caution that research on post-fledging survival associated with ANSs must be conducted before ANSs can be fully endorsed as a viable mitigation tool.